Synthesis And Biological Use As Potential Anticancer Agents

Norcantharidin and analogues: synthesis and biological use as potential anticancer agents Norcantharidin (NCTD), the demethylated analogue of cantharidin, has been used to treat human cancers in China since 1984. It was recently found to be capable of inducing apoptosis in human colon carcinoma, hepatoma and glioblastoma cells by way of an elusive mechanism.1 Norcantatharidins and their analogues are synthetic anticancer agents which have been used in various different procedures for the inducing growth arrest and apoptosis of tumour cells and also provide therapeutic and adjuvant therapeutic applications in the treatment of cancer agents.2 This report will discuss the various different NCTD that are currently being studied, highlighting the synthesis of these NCTD and their various biological pathways that are taken in order to inhibit the growth of the correspondent cancer cell. In particular NCTD induced apoptosis of the hepatoma cells will be considered and also highlighting the different views with the synthesis of the particular NCTD and also the effectiveness of th e methodology and its observations in response to other NCTD and their mechanism in attacking the hepatoma cell site. One study by Shuijun Zhanga et al had shown the ABT-737 induced apoptosis of hepatocellular carcinoma cells (HCC) by the transcriptional repression of Myeloid cell leukemia 1 (Mcl-1). Shuijun Zhanga et a. had shown that NCTD could affect apoptosis by the modification of the B-cell lymphoma 2Show MoreRelatedAnticancer Drugs : The Treatment Of Malignant Or Malignant Disease1642 Words   |  7 PagesAnticancer drugs are that are effective in the treatment of malignant or cancerous disease. These are known as antineoplastic drugs also. The drugs are involved in cancer treatment are several types. 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